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What Is Provigil ?

Provigil (modafinil) is an oral prescription medication that reduces daytime sleepiness in people with narcolepsy, obstructive sleep apnea, and shift work sleep disorder.
Provigil, a central nervous system (CNS) stimulant, is believed to work by increasing the availability of certain chemicals in the brain, most notably dopamine. Provigil is classified as a Schedule IV controlled substance. This means it has a potential for abuse and dependence but is less likely to cause dependence than stimulants like Adderall (a Schedule II controlled substance).
Modafinil is an oral drug that is used for improving wakefulness in patients with excessive sleepiness. It is similar to armodafinil (Nuvigil). Like amphetamines, modafinil promotes wakefulness by stimulatIng the brain. The exact mechanism of action of modafinil is unknown. It may work by increasing the amount of dopamine (a chemical neurotransmitter that nerves use to communicate with each other) in the brain by reducing the reuptake of dopamine into nerves. Modafinil was approved by the FDA in December 1998. You should not use this medicine if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil).
Modafinil can cause skin reactions that may be severe enough to need treatment in a hospital. Stop taking this medicine and get emergency medical help if you have a skin rash or hives, blisters or peeling, mouth sores, trouble breathing or swallowing, fever, swelling in your legs, dark urine, yellowing of your skin or eyes, or swelling in your face. Modafinil is used to promote wakefulness in patients with excessive sleepiness associated with narcolepsy, obstructive sleep apnea (in addition to treatment of the underlying obstruction), and shift work sleep disorder. Narcolepsy is a chronic disease of the brain and spinal cord characterized most commonly by a recurrent, uncontrollable desire to sleep. Shift work sleep disorder is a condition in which the normal rhythm of sleep is disturbed, often as a result of working at night. Sleep apnea is a condition where sleep is constantly interrupted at night because of pauses in breathing or shallow breathing usually due to obstruction of the upper airway.

What Is Provigil Used For ?

  • The Food and Drug Administration (FDA) has approved Provigil to improve wakefulness in adults with excessive sleepiness associated with narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder.
  • Provigil does not cure these conditions and will only work for as long as you take it.

How to Take Provigil ?

  • Take Provigil by mouth exactly as instructed by your healthcare provider. You can take it with or without food, depending on your personal preference. You should not change your dose or take it at a different time of day without speaking to your provider first.
  • Avoid drinking alcohol, driving, and engaging in any potentially dangerous activities while taking Provigil.


  • Store your Provigil at room temperature, and ensure that the pill bottle is out of reach of children and pets.
  • Off-label use means that even if a drug is not FDA approved to treat a particular condition, a healthcare provider can still prescribe it if they judge it to be medically appropriate.

Which drugs or supplements interact with modafinil?

Modafinil can decrease or increase the activity of enzymes in the liver that metabolize (eliminate) other drugs. This can result in decreased levels of some drugs that reduce their effectiveness and increased levels of other drugs that leads to their toxicity. Modafinil treatment should be carefully monitored if taken with any of these drugs. Drugs which may have reduced effectiveness if taken with modafinil include cyclosporine (Sandimmune), theophylline, and hormonal contraceptives such as progestin-only or estrogen and progesterone containing drugs (for example, Micronor, Ortho-Novum 1/50). Alternative hormonal contraceptives or an additional non-drug form of contraception should be considered during treatment with modafinil, and treatment should continue for one month after modafinil therapy ends (since the effects of modafinil on contraceptive hormones may continue for several weeks). The effects of modafinil on hormonal contraceptives occurs if the hormones are taken by mouth, patch, or implant.
Drugs that may show increased effects or toxicity if taken with modafinil include warfarin (Coumadin), diazepam (Valium), propranolol (Inderal), imipramine (Tofranil), desipramine (Norpramin), phenytoin (Dilantin) and mephenytoin (Mesantoin). 

Sleep disorders are conditions that impair a person's ability to get normal, restorative sleep. The causes of these conditions are variable and range from habits people have developed before they go to sleep to a number of medical problems that disrupt the normal sleep cycle. If you notice you have a pattern of not feeling rested in the mornings after you wake up, you should probably see your doctor to determine if you have a sleep disorder.  

What Are the Side Effects of Provigil?

Provigil has a relatively safe side effect profile. How some patients experience side effects even if they follow indications. Common, less severe ones include mild headache, backache, trouble sleeping, dizziness, nausea, indigestion, inflammation of the nose and nervousness. Users who suffered from headaches reported that increasing hydration and being sure to get enough food helped improve this side effect.
One rare but severe side effect is an extreme rash, which is evidence of certain serious medical conditions. While a mild, non-threatening rash may also occur, it is not possible to reliably predict which rashes will become more serious. As such, it is recommended that intake of Provigil be discontinued at the first sign of any rash.